Nine pathways, no composite score
Each finding stays in its own pathway. Adding them into one number would hide what is actually informative.
Personalized genomics / CardiovascularGenomics is one more input
Genomics is one more input
to clinical reasoning.
Whole-genome sequencing costs a few hundred dollars and every published association can be queried in seconds, yet genomic information has been glacially slow to reach clinical practice. At PLC we treat a patient's genome as a modern adjunct to a detailed history. This tool shows how, using the markers consumer arrays already test, for cardiovascular risk and its management.
Fifty markers, nine pathways.LDL, Lp(a), triglycerides, cholesterol absorption, artery wall, blood pressure, rhythm, and how you handle statins and clopidogrel.
Step 1
Add your raw DNA file
Works with 23andMe-style text files, AncestryDNA files, CSV, TSV, and selected single-sample SNP VCF files.
If your download is a .zip or .gz, open it first and choose the DNA file inside.Seeing the report for your own file needs a free Google sign-in. We keep your name and email, never your DNA file or results. The fictional sample needs no sign-in.Don't have a file ready?
Your DNA file stays on this device. It is matched in your browser. It is not saved or uploaded.
How we use genomic information
Some findings are directly informative. Most shift a prior.
Highly penetrant variants can change management outright; APOE status is one example. Most findings are more nuanced, and we fold them into Bayesian decision-making when choosing between essentially equal options. If your genetics suggest you retain salt, hydrochlorothiazide may reasonably be the first antihypertensive we try, assuming nothing else points elsewhere.
Tied to decisions we actually make
Which statin, whether to add ezetimibe, which first antihypertensive, whether clopidogrel will work.
Mechanism and evidence on every card
Each finding carries the physiology, an evidence label, the primary sources and the exact DNA calls behind it.
What the panel covers
Nine cardiovascular pathways
Each pathway asks a different question about cholesterol, blood vessels, heart rhythm, or medicine handling.
01LDL and ApoB
02Lipoprotein(a)
03Triglycerides and remnants
04Cholesterol absorption
05Artery-wall biology
06Statin handling
07Blood-pressure biology
08Heart-rhythm tendency
09Clopidogrel handling